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AI解码人类基因关键DNA“起始子”序列特征_我的网站

A |     研究人员利用人工智能解码基因激活中的关键DNA序列。图片来源：美国加州大学圣迭戈分校官网　　美国加州大学圣迭戈分校研究人员利用高通量DNA测序和人工智能技术，解码了人类基因中一段名为“起始子”的关键DNA序列特征。

B | 这项成果为解析基因表达调控规律和预测DNA突变影响提供了新工具。    Mohanlal has never hidden his affection for Kireedam, the 1989 drama that shaped his career and left a mark on Malayalam cinema. Now, more than three decades later, the film is back in the spotlight with a world premiere of its 4K restoration at the 56th International Film Festival of India in Goa. The actor shared his excitement on social media, calling the moment an honour and a deeply emotional milestone.A Legendary Film Finds New LightHe revealed that the film was restored from a 35mm release print preserved by the National Film Archive of India. The original camera negative had deteriorated over time, which makes the survival of this print all the more important. Mohanlal thanked the NFDC and NFAI team and highlighted how gratifying it is to see the film revived under the National Film Heritage Mission. He also noted that cinematographer S Kumar personally supervised the final grading, ensuring the restored version stays true to the film's visual soul.For fans who grew up watching Kireedam on VHS tapes and scratchy television reruns, the idea of seeing its emotional churn in crisp 4K is nothing short of a full circle moment.          Delighted to share the world premiere of the 4K restoration of Kireedam (1989), presented as part of the Special Screenings at the 56th IFFI, Goa. The film has been meticulously restored by NFDC – National Film Archive of India from a 35mm release print, thankfully preserved by…     — Mohanlal (@Mohanlal) November 26, 2025          A Story That Has Lost None of Its PowerDirected by Sibi Malayil and written by A K Lohithadas, Kireedam is remembered not for spectacle but for its simple and devastating human core. Mohanlal plays Sethumadhavan, a young man who dreams of joining the police force, only to watch his life twist into tragedy after one fateful confrontation. His performance is often cited as one of the finest in Malayalam cinema, a controlled portrayal of a man crushed by fate and circumstance. The role earned him a Special Jury Mention at the National Film Awards and remains a reference point for actors studying restrained emotional craft.The film’s influence grew with time. It inspired remakes in several languages and continues to be discussed in conversations about the best Malayalam films ever made. Critics still praise its grounded writing and its heartbreaking final stretch, both of which shaped a generation of filmmakers who admired its honesty. The restoration now gives new audiences a chance to experience the film the way it was meant to be seen on the big screen.Also Read: 36 Years of Kireedam: Why This Mohanlal Film Still MattersA Festival Spotlight on India’s Cinematic PastThe return of Kireedam is part of the Indian Panorama Special Package at IFFI 2025, which features eighteen restored classics. These restorations cut across Hindi, Malayalam, Bengali, Marathi, and Telugu cinema and honour the legacy of some of the country’s greatest storytellers. This year's programme carries even deeper meaning as it celebrates one hundred and twenty five years of V Shantaram and marks centenary tributes to legendary names such as Guru Dutt, Raj Khosla, Ritwik Ghatak, Bhupen Hazarika, P Bhanumati, Salil Choudhury, and K Vaikunt.Film enthusiasts attending the festival will notice the growing emphasis on film preservation in India. The restored lineup at IFFI reflects the larger push by the National Film Heritage Mission to protect and revive classics that risk being lost to time. With each restoration, the gap between past and present narrows. Films once limited to aging prints and memories now have a chance to thrive before a new generation.In this context, Kireedam stands as both a tribute and a reminder. It celebrates the power of performance-driven storytelling and underlines why preserving cinema matters. As Mohanlal said, watching the classic return to the screen is an honour. For audiences, it is a gift.Also Read: Fan Calls Rashmika Mandanna ‘Bhabhi’; This Is How She Reacts。相关论文发表于最新一期《基因与发育》杂志。　　人体不同类型的细胞虽然拥有基本相同的DNA，但由于被激活的基因不同，最终能够形成不同的细胞类型，并执行各自特定的功能。

C | DNA中的一些特殊片段负责精细调控基因表达，使细胞产生酶、激素、蛋白质以及维持细胞结构和功能所需的其他重要成分。如果这些基因没有被正确激活，细胞可能无法正常发挥功能，并可能引发包括癌症在内的多种疾病。　　为了进一步弄清DNA中哪些序列负责启动基因表达，研究人员将目光投向了“起始子”。这是基因表达过程中的一个重要DNA区域，是基因编码的信息开始被表达，进而产生具有功能产物的关键区域。　　研究人员利用高通量DNA测序技术，检测了约50万个不同“起始子”序列的基因表达活性。随后，他们将这些实验数据用于训练机器学习模型，使AI能够识别“起始子”特有的DNA序列模式。　　利用训练出的模型，研究人员进一步在人体基因中搜索“起始子”的特征序列，发现约60%的人类基因含有“起始子”。

D | 他们表示，这些AI模型首次能够预测人类基因中是否存在“起始子”，并解码其DNA碱基序列模式。相关数据和模型还可用于预测“起始子”相关DNA突变的影响，以及设计具有特定功能的合成启动子，即能够调控基因开启和关闭的DNA序列。　　研究人员表示，人类每个细胞中都包含约60亿个DNA碱基，其中蕴含着决定基因何时、何地，以及以多大程度表达的复杂“密码”。此次建立的“起始子”AI模型只是解析这一基因表达“密码”的一小部分，希望未来进一步扩大模型范围，以更加全面地解析人类基因表达调控规律。（记者张佳欣）。

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